Predictive Approach to Understand and Eliminate Tablet Breakage During Film Coating

Pharmaceutical tablets can be susceptible to damage such as edge chipping or erosion of the core during tablet coating process. The intersection certain process parameters, equipment design, and properties may induce more significant complete fracture. In this work, a hybrid predictive approach was developed using discrete element method (DEM) modeling lab-based impact experiments identify conditions that lead breakage events. extended examine potential modifications in silico mitigate likelihood future batches. is shown enhance understanding, optimal within development constraints, de-risk manufacture